One Body. Seventy-Eight Organs. One Coordinated Aging Story

The body’s organs do not age at the same rate. A heart can be biologically older than its kidneys; a brain can be younger than its liver. The CureForge 78-Organ Institute is the federation’s research engine for organ-level aging trajectories across the human body. A per-organ inference tree delivers organ-specific aging biomarkers; a cross-organ pleiotropy predictor identifies when a single intervention will have effects across multiple organ systems; a disease-organ routing fabric directs disease vertical institutes to the right organ-level aging trajectory; and a federated cross-organ Bayesian effect coordinator integrates evidence across organ clocks at population scale. Every other disease vertical in the CureForge federation pulls from this institute for its organ-specific aging context. The result is the foundation that no singleorgan aging program can match.

Value proposition:

• Federated organ-clock coverage across the human body
• Cross-organ pleiotropy detection for whole-body intervention design
• Per-organ aging trajectories integrated across population-scale cohorts