Post-Market Surveillance, At Federation Scale

Drug safety does not end when a drug is approved. It begins. The CureForge Pharmacovigilance & Safety Institute is the federation’s research engine for post-market surveillance. Ten specialized AI systems collaborate across continuous monitoring of major U.S., European, and global pharmacovigilance databases, federation-site adverse-event aggregation, signal detection through disproportionality analysis and Bayesian shrinkage methods, causality assessment using validated clinical algorithms, periodic safety update report drafting, risk management plan coordination, an adverse-event knowledge graph that cross-references with the federation’s scientific-knowledge audit institute for retraction correction, and federation-wide cross-vertical safety signal aggregation. The institute is the federation’s continuous safety substrate after marketing.

Value proposition:

• Continuous monitoring of major global pharmacovigilance databases
• Signal detection through disproportionality analysis and Bayesian shrinkage
• Cross-vertical federation-wide safety signal aggregation