Medicine for One

Most current “personalized medicine” stratifies patients into subgroups. True N-of-one medicine asks a different question: what is optimal for this specific human? Recent landmark publications of patient-specific gene-editing therapy designed for a single infant established the regulatory and ethical model for individualized medicine. The CureForge Personalized Medicine & N=1 Trials Institute productizes that capability across every therapeutic vertical in the federation. Ten specialized AI systems collaborate across patient-specific multi-omic profiling, n-of-one synthetic-control-arm design through the federation’s synthetic-data-generation institute, personalized drug repurposing, n-of-one gene therapy designer coordinated with the gene-editing institute, Bayesian adaptive personal trial design, patient-specific combination therapy, patient digital twins, personal-genomic privacy through trustedexecution-environment computation, n-of-one regulatory pathway navigation, and lifelong personalized escape-velocity modeling.

Value proposition:

• True N-of-one therapy design across every federation therapeutic vertical
• Synthetic control arms as patient-specific counterfactuals
• Personal-genomic privacy through trusted-execution-environment compute